Advanced Understanding of the Electron Transfer Pathway of Cytochrome P450s

Cytochrome P450s are heme-thiolate enzymes that participate in carbon source assimilation, natural compound biosynthesis and xenobiotic metabolism in all kingdoms of life. P450s can catalyze various reactions by using a wide range of organic compounds, thus exhibiting great potential in biotechnological applications. The catalytic reactions of P450s are driven by electron equivalents that are sourced from pyridine nucleotides and delivered by cognate or matching redox partners (RPs). The electron transfer (ET) route from RPs to P450s involves one or more redox center-containing domains. As the rate of ET is one of the main determinants of P450 efficacy, an in-depth understanding of the P450 ET pathway should increase our knowledge of these important enzymes and benefit their further applications. Here, the various P450 RP systems along with current understanding of their ET routes will be reviewed. Notably, state-of-the-art structural studies of the two main types of self-sufficient P450 will also be summarized.     

反坦克导弹用热电池研究进展

反坦克导弹作为击毁坦克和其他装甲目标的武器装备,在国家安全领域具有重要地位.热电池作为反坦克导弹的能源系统,对导弹功能实现具有重要意义.围绕反坦克导弹用热电池快激活和瞬时高比功率技术,结合热电池电化学材料体系发展历史、现状,探讨了提升快激活能力,提高瞬时比功率输出能力的技术,并对技术发展趋势进行了展望.     

BOPET薄膜市场现状分析及发展趋势

基础BOPET全球生产市场需求分析,尤其对中国BOPET的市场需求、市场分布、生产厂家、产能等全方面进行了分析,得出BOPET行业市场发展将向再生利用、生物可降解、绿色改性以及降低单耗等五方面可持续发展.     

Highly oriented α-Al2O3 transparent ceramics shaped by shear force

Alumina platelets were arranged horizontally in submicron alumina particles by shear force in the flow of slurries during casting. The obtained alumina green bodies with platelets were pressureless-sintered in vacuum, producing ceramics with thoroughly oriented grains and high transmittance. The effects of sintering parameters on the densification, microstructure evolution, and orientation degree of alumina ceramics were investigated and discussed. The results showed that the densification, grain size, orientation degree, and in-line transmittance were increased with increasing sintering temperature. The enhancement of orientation degree was mainly coherent with grain growth. The grain-oriented samples exhibited a much higher in-line transmittance (at 600 nm) of 61 % than that of the grain random sample (29 %). Moreover, the transmission remained a high level in the ultraviolet range (<300 nm).     

Research on phase shift characteristics of electromagnetic wave in plasma

The phase shift characteristics reflect the state change of electromagnetic wave in plasma sheath and can be used to reveal deeply the action mechanism between electromagnetic wave and plasma sheath. In this paper, the phase shift characteristics of electromagnetic wave propagation in plasma were investigated. Firstly, the impact factors of phase shift including electron density,collision frequency and incident frequency were discussed. Then, the plasma with different electron density distribution profiles were employed to investigate the influence on the phase shift characteristics. In a real case, the plasma sheath around the hypersonic vehicle will affect and even break down the communication. Based on the hypersonic vehicle model, we studied the electromagnetic wave phase shift under different flight altitude, speed, and attack angle. The results indicate that the phase shift is inversely proportional to the flight altitude and positively proportional to the flight speed and attack angle. Our work provides a theoretical guidance for the further research of phase shift characteristics and parameters inversion in plasma.     

二次喷丸诱导应力及变形工程预测方法

为建立二次喷丸的等效分析方法,在单次喷丸诱导应力及饱和度已知的情况下,进行金属零件二次喷丸的诱导应力和变形的工程预测.以单次喷丸的饱和度曲线为分析基础,讨论了二次喷丸饱和度与喷丸时间的变化规律.用正弦函数的形式表达喷丸诱导应力,并建立了零件的平均诱导应力和饱和度之间的关系.结果表明:针对弹丸尺寸不同的二次喷丸过程,进行了基于多弹丸随机喷丸技术的有限元仿真,得到的喷丸诱导应力与理论结果相差5％左右;针对喷丸压力不同的二次喷丸过程,使用标准阿尔门试片进行了喷丸试验,试片变形与理论结果相差3％左右.仿真和试验结果均表明提出的预测方法有效、准确,可较好地预测二次喷丸后零件的残余应力和变形.     

数控机床大功率DC-DC转换器设计与控制

针对数控机床行业中使用的大功率DC-DC转换器,提出一种适用于大功率应用场合的LCL型dc/dc转换器的改进设计方法.基于零无功功率和有功功率平衡条件,结合电压和电流的P-Q理论方法,设计LCL型dc/dc变换器以实现更高的电压阶跃比,并限制电容器电压.依据提出的方法设计转换器参数,并搭建仿真模型对设计方案进行验证.仿真结果显示,转换器能实现300 kV/20kV的大功率DC-DC转换,电压阶跃比高且系统稳定性较好.说明所提出设计方法可用于数控机床中大功率高阶跃比DC-DC转换器设计与控制.     

弹性元件参数优化对扑翼机构转速波动影响研究

以特拉华大学机械系统实验室所研制的样机模型进行建模,该模型传动机构采用曲柄摇杆机构.传动机构在运转的过程中,翅翼会在气动力和惯性力作用下产生周期性波动,导致电机转速波动增大,影响机构的平稳运行,产生振动和噪声.在仿真试验中引入弹簧元件,可有效降低电机转速波动,利用正交试验设计方法对影响电机转速波动的影响因素进行极差分析,得出弹簧的连接点位置是主要因素,弹簧的刚度系数是次要因素,弹簧原长影响最小.搭建了物理实验平台,验证了仿真结果和正交试验设计方法的正确性.     

N-苄氧羰基甘氨酰-L-脯氨酸与4'-去甲基表鬼臼毒素的拼接合成及其抗肿瘤活性评价

以4'-去甲基表鬼臼毒素和N-苄氧羰基甘氨酰-L-脯氨酸为原料,通过酯化反应首次得到两种不同构型的拼接产物(3a、3b),其结构经1HNMR、13C NMR和ESI-MS确认.利用MTT法考察化合物3a、3b对HepG2、THP-1、Hela、MCF-7细胞的抑制活性.结果表明,化合物3a、3b对四种细胞都具有抑制作用,以化合物3b对THP-1细胞的作用最突出,其抑制强度是依托泊苷的16.5倍.